Which Covid-19 Vaccine Will Keep You Alive or Out of The Hospital?

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Which covid vaccine keep you alive or out of hosptial The goal of a vaccine program for Covid-19 is not necessarily to get to ‘Covid zero,’ but it is to tame this virus, to defend it, to remove its ability to cause serious disease, hospitalization, and death.

Here we talk about vaccine efficacy rates.  Clinical trials are what test the efficiency rate of a vaccine. Thousands of people get a vaccine tested on them. Those people are broken into two groups: half gets the vaccine, and half get a placebo. Then, they go on and live their lives, while scientists monitor them, whether or not they get Covid-19 over several months.

In Trial, There were 43,000 participants. In the end, 170 people got Covid-19. In addition, how those people fall into each of these groups determines a vaccine’s efficacy. If the 170 were evenly split, that would mean you are just as likely to get sick with the vaccine as without it. Therefore, it would have a 0% efficacy. If all 170 were in the placebo group, and zero people who got the vaccine were sick, the vaccine would have an efficacy of 100%.

With this particular trial, there were 162 in the placebo group, and just eight in the vaccine group. It means those who had the vaccine were 95% less likely to get Covid-19 that is, the vaccine had a 95% efficacy.

Now, this does not mean that if 100 people get the vaccine, five of them will get sick. Instead, that 95% number applies to the individual. Therefore, each vaccinated person is 95% less likely than a person without a vaccine to get sick, each time they get exposed to Covid-19.

In the same way every vaccines efficiency rate is calculated. Nevertheless, each vaccine trial might be done is very different circumstances.

Moreover so, one of the biggest considerations here, when we look at these numbers, is the timing in which these clinical trials were performed. This is the number of daily Covid-19 cases in the US since the pandemic began.

The Moderna trial commenced and completed in the U.S., here, in the summer. The Pfizer/BioNTech trial primarily based in the US and at the same time Johnson &Johnson, however, held their US trial at this time, when there were more opportunities for participants to be exposed to infections. However, most of their trial took place in other countries, primarily South Africa and Brazil. In addition, these other countries, not only were case rates high, but the virus itself was different.

The trials took place as variants of Covid-19 emerged, and became the dominant infection in these countries; variants that are more likely to get participants sick.

In South Africa, most of the cases in the Johnson &Johnson trial were that of the variant, not the original strain that was in the US over the summer. Moreover, despite that, it still significantly reduced infections.

If you are trying to make one-to-one, head-to-head comparisons between vaccines, they need to have study in the same trial, with the same inclusion criteria, in the same parts of the world, at the same time. If we were to take Pfizer and Moderna’s vaccines, and redo their clinical trial at the same time that we saw J&J’s clinical trial, we might see quite different efficacy numbers for those. These efficacy numbers really just tell you what happened in each vaccine’s trial, not exactly what will happen in the real world.

 

But many experts argue this isn’t even the best number to judge a vaccine by anyway. Because preventing any infection at all is not always the point of a vaccine.

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